WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
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چکیده
منابع مشابه
WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for ciliogenesis. Disruption of WDR11 expression in mouse and...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201744632